2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140756
    Azido-PEG1-NHS ester 1807530-06-8 99.78%
    Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-NHS ester
  • HY-W040134
    Mal-amido-PEG4-NHS ester 756525-99-2 99.24%
    Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG4-NHS ester
  • HY-124323
    m-PEG4-NHS ester 622405-78-1
    m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-NHS ester
  • HY-135821
    Fmoc-NH-PEG12-CH2CH2COOH 1952360-91-6 99.96%
    Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG12-CH2CH2COOH
  • HY-135796
    m-PEG3-OH 112-35-6 99.86%
    m-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG3-OH
  • HY-42145
    3-Maleimidopropionic acid 7423-55-4 99.83%
    3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-Maleimidopropionic acid
  • HY-W004697
    Boc-GABA-OH 57294-38-9 99.14%
    Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC.
    Boc-GABA-OH
  • HY-140761
    Azido-PEG16-NHS ester 2553413-74-2 99.91%
    Azido-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG16-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG16-NHS ester
  • HY-141364
    Bromo-PEG1-C2-Boc 1393330-36-3 98.58%
    Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG1-C2-Boc
  • HY-130175
    Fmoc-NH-PEG4-CH2COOH 437655-95-3 99.11%
    Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG4-CH2COOH
  • HY-40142
    1-N-Boc-3-hydroxyazetidine 141699-55-0 99.63%
    1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    1-N-Boc-3-hydroxyazetidine
  • HY-77483
    tert-butyl (5-bromopentyl)carbamate 83948-54-3 99.25%
    tert-butyl (5-bromopentyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-butyl (5-bromopentyl)carbamate
  • HY-20236
    2-Boc-2-Azaspiro[3.3]heptane-OH 1147557-97-8 99.99%
    2-Boc-2-Azaspiro[3.3]heptane-OH is a PROTAC linker that can be used in the synthesis of PROTACs.
    2-Boc-2-Azaspiro[3.3]heptane-OH
  • HY-W055870
    Hydroxy-PEG1-(CH2)2-Boc 671802-00-9 99.96%
    Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG1-(CH2)2-Boc
  • HY-140661
    Azide-PEG2000-amine
    Azide-PEG2000-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG2000-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG2000-amine
  • HY-140070
    endo-BCN-PEG8-NHS ester 1608140-48-2
    endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG8-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG8-NHS ester
  • HY-I0781
    Boc-Hyp-OH 13726-69-7 99.57%
    Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
    Boc-Hyp-OH
  • HY-140009
    Azido-PEG1-C2-acid 1393330-34-1 98.0%
    Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-C2-acid
  • HY-22335
    Amino-PEG4-C2-amine 68960-97-4 98.0%
    Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG4-C2-amine
  • HY-W018745
    Tetraethylene glycol 112-60-7 99.97%
    Tetraethylene glycol (PROTAC Linker 18) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tetraethylene glycol
PROTAC Linkers Isoform Comparison

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